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Our Research
Evolutionary genomic studies of PvDBP
2014-2019
The hunt for signatures of selection in the field of malaria is accomplished at different levels by means of comparative data analysis and exploring parasite’s genetic diversity patterns. As a result, application of evolutionary genomic models will aid in unravelling the genetic contribution of antigenic variants in Plasmodium, which will help in designing a promising vaccine to eliminate P. vivax malaria.
Molecular and evolutionary genetic analysis of putative CSP
2015-2019
To understand the genetic variation and structure of putative PvpuCSP gene of Plasmodium vivax in Indian isolates through population genetics and molecular evolutionary approach. The gene will also be looking for any signature of selection, since significant reduced genetic diversity has been reported in the nearby putatively neutral regions, as per the neutral model of molecular molecular hitchhiking/ selective sweep.
Molecular approach to detect all human malaria parasite species
2017-Present
Diagnostic purpose using single PCR
Liver stage Biology
2016-PRESENT
Some of the primary objectives Malaria liver stage research are (i) to investigate on proteins that are secreted by sporozoites during hepatic cell invasion followed by (ii) studies on cell traversal, persistence of parasite in liver cells and (iii) proteins behind the exit mechanism of parasite from hepatocyte, (iv) molecular machinery involved in trafficking of proteins. Early stage approaches used to explore these objectives will include molecular biology, protein biochemistry, cell culture, protein crystallography and bioinformatic analysis. Other than basic research, I am also working to develop an assay for species specific detection of malaria parasites.
Biology of mixed malaria infection
2019-2022
Main focus of this project is to investigate the clinical consequences of mixed P. falciparum and P. vivax infections in terms of clinical complications and the rate of annual relapse in such cases. Also, a developing a method to separate the two species from mixed infection which will add a tool to better understand the clinical biology of such mixed infections. Apart from this, exploring the possibility of hetero-specific interaction between the two species when present inside the same host together.
Reverse genetics in Plasmodium berghei
2017-2020
Using Knockout technology
Activation of gametocytes
2018-2020
investigate the role of XA alone in premature activation of male gametocytes in-vitro as well as in-vivo mouse models and in subsequent blocking of parasite transmission.
Link between Malaria & Hypertension
2017-2020
A very interesting cross-disease study which is trying to find a link between malaria and hypertension via RAS.
Reactive versus active case to search for indigenous transmission
2018-Present
By checkerboard method
Switchable Nanogels
2018-Present
This study is to test mosquitocidal effectiveness of prepared nanogel on different vector species. Proof of principle study, if proven successful, can be developed as a “lure, suck and kill” technology to kill mosquitoes using mosquito-attractant compounds into the nanogel.
